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Mononucleosis (glandular fever)

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This infectious disease, Infectious Monocleosis or Glandular Fever, is caused by a virus, the name of which is the Epstein-Barr virus (E.B.V.).

Young adults are predominantly affected and the virus is invariably spread by saliva, as in kissing.

Clinically the patient develops a fever, becomes unusually tired, has a sore throat and may develop a rash which may be of brief duration. Many patients have no symptoms at all though. There may be enlargement of the lymphatic glands particularly in the neck area. The spleen may be enlarged and this will be detected on clinical examination.

There can be complications (Menigitis) - fortunately this is rare. Blood investigation will reveal lymphocytes which are atypical. The diagnosis is confirmed if a reaction, know as the Paul-Bunnell reaction, is positive (this is an agglutination or clumping of sheep red cells by heterophile antibodies).


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