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Gallstones

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Gallstones are formed in the gallbladder as stones from cholesterol, bile salts and calcium. They are present in 10-20% of the population and are most common in women, particularly those who are overweight. Most of these stones remain in situ and cause no clinical problems. Problems arise when they move out into the cystic duct where they tend to become impacted causing inflammation of the gallbladder (cholecystitis).

Gallstones come in two main types:

The cholesterol stone, composed mainly of cholesterol, accounts for 80% of all stones removed from patients in the Western world. These stones form in the presence of bile, which has an excess of cholesterol relative to bile salts and other constituents.

Pigment stones, are mainly composed of compounds containing bilirubin polymers and calcium bilirubinate complete the second category.

Symptoms of gallstones may include:

Acute cholecystitis results in constant severe pain in the upper right abdomen near the ribcage. This pain usually radiates to the back and commonly to the tip of the right shoulder and is often accompanied by a high temperature. There may be vomiting, jaundice and certainly nausea. On examination the classical Murphy's sign can be elucidated - pain under the right ribcage which is worse on inhalation. Acute cholecystitis patients may not necessarily have gallstones but often do. Urine will be examined for any change in colour and further investigations in hospital may be arranged. If jaundice is marked, indicating an almost certain obstruction, urgent admission to hospital will be carried out.

Chronic cholecystitis which is also known as biliary colic is a chronic inflammation of the gallbladder. It is often found in association with the gallbladder but, may not produce symptoms and therefore, removal of the gallbladder is not advocated unless the condition proceeds to the acute phase. Symptoms include pains in the center the upper abdomen, or on the right side below the ribs. Nausea and vomiting may sometimes present. The pain can radiate to in between the shoulder blades or the right shoulder. Episodes may be, but are not always triggered by eating fatty foods.

Jaundice may result if there is blockage of the flow of bile to the liver. It presents as a yellowing of the skin and whites of the eyes. Pale stools and dark urine may also be features. Not all cases of jaundice are due to gallstones.

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